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Background  Few studies have assessed the time to blood culture positivity as a predictor of clinical outcome in fungal bloodstream infections (BSIs). The purpose of this study was to evaluate the time to positivity (TTP) of blood cultures in patients with  Candida albicans  BSIs and to assess its impact on clinical outcome.    Methods  A historical cohort study with 89 adults patients with  C. albicans  BSIs. TTP was defined as the time between the start of incubation and the time that the automated alert signal indicating growth in the culture bottle sounded.    Results  Patients with BSIs and TTPs of culture of ≤36 h (n=39) and >36 h (n=50) were compared. Septic shock occurred in 46.2% of patients with TTPs of ≤36 h and in 40.0% of patients with TTP of >36 h (p=0.56). A central venous catheter source was more common with a BSI TTP of ≤36 h (p=0.04). Univariate analyis revealed that APACHE II score≥20 at BSI onset, the development of at least one organ system failure (respiratory, cardiovascular, renal, hematologic, or hepatic), SOFA at BSI onset, SAPS II at BSI onset, and time to positivity were associated with death. By using logistic regression analysis, the only independent predictor of death was time to positivity (1.04; 95% CI, 1.0-1.1, p=0.035), with the chance of the patient with  C. albicans  BSI dying increasing 4.0% every hour prior to culture positivity.    Conclusion  A longer time to positivity was associated with a higher mortality for  Candida albicans  BSIs; therefore, initiating empiric treatment with antifungals may improve outcomes.

Time to blood culture positivity as a predictor of clinical outcome in patients with Candida albicansbloodstream infection