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Background   Helicobacter pylori  infection is acquired in early childhood and persists for life (or until eradication treatment is taken). Seropositivity of  H. pylori  at age 49-51 years was assessed in relation to socio-economic deprivation in early life and the timing of other childhood infections common at that time.    Methods  Prospectively collected socio-economic and morbidity data from the Newcastle Thousand Families study, a birth cohort established in 1947.  H. pylori  IgG seropositivity was assessed at 49-51 years and examined in relation to both whether the individual had been diagnosed with one of measles, mumps or chicken pox, and, if so, the age at first infection. This was done in logistic regression models, allowing adjustment for socio-economic status and housing quality in childhood.    Results  Adult  H. pylori  status was strongly linked to disadvantaged socio-economic status in early life (p ≤ 0.002), unlike measles, mumps and chicken pox which showed no associations. Early measles infection was independently associated with  H. pylori  seropositivity (p = 0.01).    Conclusions  Of the four infectious diseases that we have studied, it appears that  H. pylori  differs from the others by the strength of association with socio economic deprivation in early childhood.  Our findings further highlight the complex interaction between measles, childhood infections and other non-microbiological factors that occur within a whole population. These data suggest a strong association between H. pylori and deprivation and raise the possibility of an interaction between early measles exposure and increased risk of exposure to  H. pylori  infection.

Deprivation, timing of preschool infections and H. pylori seropositivity at age 49-51 years: the Newcastle thousand families birth cohort