English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  Invasive candidiasis is an important nosocomial infection associated with high mortality among immunosuppressive or critically ill patients. We described the incidence of invasive candidiasis in our hospital over 6 years and showed the antifungal susceptibility and genotypes of the isolated yeast.    Method  The yeast species were isolated on CHROMagar  Candida  medium and identified using an yeast identification card, followed by analysis of the D1/D2 domain of 26S rDNA. The susceptibilities of the isolates to flucytosine, amphotericin B, fluconazole, itraconazole, and voriconazole were tested using the ATB FUNGUS 3 system, and that to caspofungin was tested using E-test strips.  C. albicans  was genotyped using single-strand conformation polymorphism of CAI ( Candida albicans  I) microsatellite DNA combined with GeneScan data.    Results  From January 2006 to December 2011, a total of 259 isolates of invasive  Candida  spp. were obtained from 253 patients, among them 6 patients had multiple positive samples. Ninety-one stains were from blood and 168 from sterile fluids, accounting for 6.07% of all pathogens isolated in our hospital. Most of these strains were  C. albicans  (41.29% in blood/59.06% in sterile body fluids), followed by  C. tropicalis  (18.06%/25.72%),  C. parapsilosis  (17.42%/5.43%),  C. glabrata  (11.61%/3.99%) and other  Candida  spp. (11.61%/5.80%). Most  Candida  spp. were isolated from the ICU. The new species-specific CLSI  candida  MIC breakpoints were applied to these date. Resistance to fluconazole occurred in 6.6% of  C. albicans  isolates, 10.6% of  C. tropicalis  isolates and 15.0% of  C. glabrata  isolates. For the 136  C. albicans  isolates, 54 CAI patterns were recognized. The  C. albicans  strains from blood or sterile body fluids showed no predominant CAI genotypes.  C. albicans  isolates from different samples from the same patient had the same genotype.    Conclusions  Invasive candidiasis has been commonly encountered in our hospital in the past 6 years, with increasing frequency of non -C. albicans . Resistance to fluconazole was highly predictive of resistance to voriconazole. CAI SSCP genotyping showed that all  C. albicans  strains were polymorphic. Invasive candidiasis were commonly endogenous infection.

bmc infectious diseases

Surveillance of the prevalence, antibiotic susceptibility, and genotypic characterization of invasive candidiasis in a teaching hospital in China between 2006 to 2011