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Background Fusidic acid (FA)an inhibitor of protein synthesis has been used for treating superficial and some systemic infections caused by Staphylococcus aureus. Fusidic acid resistance in S. aureus has been reported throughout the world with prevalence ranging from 0.5% to 50% and is due to i) point mutation in bacterial fusA or fusE gene and ii) by acquired FA resistance determinants fusB, C and D. Indian report of fusidic acid resistant S. aureus (FRSA) is based on phenotypic detection. Hence, this study was done to detect acquired FA resistance determinants.

bmc infectious diseases

Detection of fusidic acid resistance determinants among Staphylococcus aureus isolates causing skin and soft tissue infections from a tertiary care centre in Chennai, South India