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Background HLA alleles are associated with differential outcomes of infections/diseases. We hypothesize that epitopes that interact with HLA alleles associated with resistance elicit a protective immune response in the host, and could therefore serve as good vaccine candidates. Among the HLA alleles reported to be associated with resistance to HIV infection/slow progression to AIDS, HLA-A*0201 occurs most frequently in the Indian population. We undertook this study to identify HIV epitopes specific to this HLA allele from HIV-1C.

HLA-A*0201-specific epitopes of Indian HIV-1C as candidates for vaccine design