English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Currently available tools cannot be used to distinguish between sub-species of the  M. tuberculosis  complex causing latent tuberculosis (TB) infection.  M. africanum  causes up to half of TB in West- Africa and its relatively lower progression to disease suggests the presence of a large reservoir of latent infection relative to  M. tuberculosis .    Methods  We assessed the immunogenicity of the TbD1 region, present in  M. africanum  and absent from "modern"  M. tuberculosis , in an ELISPOT assay using cells from confirmed  M. africanum  or  M. tuberculosis  infected TB patients without HIV infection in the Gambia.    Results  Antigens from the TbD1 region induced IFNγ responses in only 35% patients and did not discriminate between patients infected with  M. africanum  vs.  M. tuberculosis , while PPD induced universally high responses.    Conclusions  Further studies will need to assess other antigens unique to  M. africanum  that may induce discriminatory immune responses.

Immunogenicity of antigens from the TbD1 region present in M. africanum and missing from "modern" M. tuberculosis: a cross- sectional study