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Background  Aging in animals is associated with high body oxidative stress, which might affect susceptibility and onset of age-related diseases, and the subsequent life span. Therefore, genes that modulate oxidative stress might play a role in determining longevity. In this study, we investigated whether the gene pool relevant to the  SOD2 -9T/C and  MTHFR  677C/T polymorphisms changes as the Jordanian population ages.    Methods  Polymorphisms were genotyped in 130 elderly subjects (57 females and 73 males, mean age: 90.01 years) and 135 young control subjects (67 females and 68 males, mean age: 33.43 years).    Results  No significant differences were found in the genotype and allele frequencies of examined  SOD2  and  MTHFR  gene variants between the elderly group and young controls ( P  > 0.05), nor when each gender was considered separately ( P  > 0.05).    Conclusion   SOD2 -9T/C and  MTHFR  677C/T gene polymorphisms do not seem to be important in Jordanian population for longevity phenotype.

Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population