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Background   Mycoplasma hyorhinis  infection has been postulated to play a role in the development of several types of cancer, but the direct evidence and mechanism remained to be determined.    Methods  Immunohistochemistry assay and nested polymerase-chain reaction (PCR) were performed to examine the  mycoplasma hyorhinis  infection in gastric cancer tissues. Statistical analysis was used to check the association between mycoplasma infection and clinicopathologic parameters. Transwell chamber assay and metastasis assay were used to evaluate  mycoplasma hyorhinis ' effects on metastasis in vitro and in vivo.  Mycoplasma hyorhinis -induced extracellular signal-regulated kinase (ERK) and epidermal growth factor receptor (EGFR) activation were investigated by Western blot.    Results  My coplasma hyorhinis  infection in gastric cancer tissues was revealed and statistical analysis indicated a significant association between mycoplasma infections and lymph node metastasis, Lauren's Classification, TNM stage, and age of the patients.  Mycoplasma hyorhinis  promoted tumor cell migration, invasion and metastasis  in vitro  and  in vivo , which was possibly associated with the enhanced phosphorylation of EGFR and ERK1/2. The antibody against p37 protein of  Mycoplasma hyorhinis  could inhibit the migration of the infected cells.    Conclusions  The infection of  m y coplasma hyorhinis  may contribute to the development of gastric cancer and  Mycoplasma hyorhinis -induced malignant phenotypes were possibly mediated by p37.

Mycoplasma hyorhinisinfection in gastric carcinoma and its effects on the malignant phenotypes of gastric cancer cells