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Background  Colorectal cancer is one kind of frequent malignant tumors of the digestive tract which gets high morbidity and mortality allover the world. Despite the promising clinical results recently, less information is available regarding the perioperative immunological effects of laparoscopic surgery when compared with the open surgery. This study aimed to compare the cellular immune responses of patients who underwent laparoscopic(LCR) and open resections(OCR) for colorectal cancer.    Methods  Between Mar 2009 and Sep 2009, 35 patients with colorectal carcinoma underwent LCR by laparoscopic surgeon. These patients were compared with 33 cases underwent conventional OCR by colorectal surgeon. Clinical data about the patients were collected prospectively. Comparison of the operative details and postoperative outcomes between laparoscopic and open resection was performed. Peripheral venous blood samples from these 68 patients were taken prior to surgery as well as on postoperative days(POD) 1, 4 and 7. Cell counts of total white blood cells, neutrophils, lymphocyte subpopulations, natural killer(NK) cells as well as CRP were determined by blood counting instrument, flow cytometry and hematology analyzer.    Results  There was no difference in the age, gender and tumor status between the two groups. The operating time was a little longer in the laparoscopic group ( P  > 0.05), but the blood loss was less ( P  = 0.039). Patients with laparoscopic resection had earlier return of bowel function and earlier resumption of diet as well as shorter median hospital stay ( P  < 0.001). Compared with OCR group, cell numbers of total lymphocytes, CD4 + T cells and CD8 + T cells were significant more in LCR group ( P  < 0.05) on POD 4, while there was no difference in the CD45RO + T or NK cell numbers between the two groups. Cellular immune responds were similar between the two groups on POD1 and POD7.    Conclusions  Laparoscopic colorectal resection gets less surgery stress and short-term advantages compared with open resection. Cellular immune respond appears to be less affected by laparoscopic colorectal resection when compared with open resection.

Laparoscopic and open resection for colorectal cancer: an evaluation of cellular immunity