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Background  Peroxisome proliferator-activated receptors (PPARs) play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD).    Aim  to assess the effect of functional single nucleotide polymorphisms (SNPs) of  PPARα  and  PPARγ2 , previously associated with insulin resistance and dyslipidemia, on liver damage in NAFLD, whose progression is influenced by metabolic abnormalities and inherited factors.    Methods  The Leu162Val  PPARα  and Pro12Ala  PPARγ2  SNPs were evaluated by restriction analysis. We considered 202 Italian patients with biopsy-proven NAFLD.    Results  The frequency of the evaluated SNPs did not differ between patients and 346 healthy controls. The presence of the  PPARα  162Val allele (prevalence 57%), but not of the  PPARγ2  12Ala allele (prevalence 18%), was associated with higher insulin resistance (HOMA-IR index 4.71 ± 3.8 vs. 3.58 ± 2.7, p = 0.026), but not with hyperglycemia. The  PPARα  162Val and  PPARγ2  12Ala alleles were not associated with the severity of steatosis, necroinflammation, or fibrosis.    Conclusions  The presence of the  PPARα  162Val allele was associated with insulin resistance, but not with liver damage in NAFLD. Because of the limited power of the present sample, larger studies are needed to exclude a minor effect of the  PPARγ2  12Ala allele on necroinflammation/fibrosis in NAFLD.

bmc gastroenterology

Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study