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Background  The plant hormone auxin exerts many of its effects on growth and development by controlling transcription of downstream genes. The  Arabidopsis  gene  AXR3/IAA17  encodes a member of the Aux/IAA family of auxin responsive transcriptional repressors. Semi-dominant mutations in  AXR3  result in an increased amplitude of auxin responses due to hyperstabilisation of the encoded protein. The aim of this study was to identify novel genes involved in auxin signal transduction by screening for second site mutations that modify the  axr3-1  gain-of-function phenotype.    Results  We present the isolation of the  partial suppressor of axr3-1  ( pax1-1 ) mutant, which partially suppresses almost every aspect of the  axr3-1  phenotype, and that of the weaker  axr3-3  allele. axr3-1 protein turnover does not appear to be altered by  pax1-1 . However, expression of an  AXR3 :: GUS  reporter is reduced in a  pax1-1  background, suggesting that  PAX1  positively regulates  AXR3  transcription. The  pax1-1  mutation also affects the phenotypes conferred by stabilising mutations in other Aux/IAA proteins; however, the interactions are more complex than with  axr3-1 .    Conclusion  We propose that  PAX1  influences auxin response  via  its effects on  AXR3  expression and that it regulates other  Aux/IAA s secondarily.

pax1-1 partially suppresses gain-of-function mutations in Arabidopsis AXR3/IAA17