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Background Microtubules are highly dynamic assemblies of the protein tubulin. Their dynamic behaviour is crucial to mitosis, the process of chromosomal division to form new cells. Microtubule dynamics are highly regulated during the cell cycle by endogenous cellular regulators. In addition, many antimitotic drugs and natural compounds alter the polymerisation dynamics of microtubules, blocking mitosis, and consequently, inducing cell death by apoptosis [1]. The drugs bind to diverse sites on tubulin and at different positions within the microtubule, and they have diverse effects on microtubule dynamics. However, by their common mechanism of suppression microtubule dynamics, they all block mitosis at the metaphase/ anaphase transition, and induce cell death. After treatment with different anti-tubulin drugs, it was also demonstrated that apoptosis occurs either in the interphase or in mitosis depending on the cell type and experimental conditions [2,3].

Nocodazole provokes an apoptosis in isopropyl-N-phenyl carbamate resistant and sensitive Nicotianalines but in two different ways