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Background Before the discovery of STIM and Orai proteins, mammalian TRPC channels, including TRPC3, were considered as candidates for mediating store-operated Ca2+ entry (SOCE). This calcium entry pathway governs diverse cellular processes from exocytosis, cellular remodelling to gene transcription. Although a prominent role of Orai1 is now well established for immune cells, the role of TRPC proteins and the possible crosstalk between these two ion channels families to the overall store operated calcium entry into cells of the immune system is still elusive.

Store-operated calcium entry into rat basophil leukaemia cells: contribution of TRPC3 and Orai1