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Background Cyclic nucleotide-gated (CNG) channels are members of the superfamily of pore loop cation channels that are activated by the binding of cGMP or cAMP. The channels are important cellular switches which transduce changes in intracellular levels of cyclic nucleotides into changes of the membrane potential and the Ca2+ concentration. CNG channels play a central role in the signal transduction pathways of vision and olfaction. We have studied the physiological significance of a particular member of the CNG channel family, CNGB1. The two splicing variants of CNGB1, termed CNGB1a and CNGB1b, assemble with CNGA1 and CNGA2/4 to form the native tetrameric CNG channels of rod photoreceptors and olfactory neurons, respectively.

Physiological roles of cGMP-gated channels: lessons from mouse models and human channelopathies