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Background It is well established that physical training promotes beneficial effects on the vascular reactivity by improving the NO/cGMP signaling pathway [1]. L-Arginine (L-Arg) is a non-essential amino acid which plays a critical role in many organism functions such as pH regulation and endothelial cell membrane depolarization. Moreover, the benefits of the oral supplemention with L-Arg have been shown in hypercholesterolemic patients by inhibition of platelet aggregation and reduction of monocytes adhesion. In hypertensive rats, L-Arg supplemention reduces cardiac noradrenergic neurotransmission and enhanced angiogenesis in the hypoxic pulmonary hypertension. Although in human subjects the acute administration of L-Arg did not change hemodynamic and vascular responses to resistance exercise, no studies exist investigating the effect of chronic administration of L-Arg associated with dynamic exercise in the vascular responsiveness in rats. Thus, the aim of this work was to investigate the effect of L-Arg supplementation on the responsiveness of aortic rings in trained rats.

L-arginine supplementation improves aortic vascular relaxation via NO-independent sGC/cGMP signaling in exercised rats