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Background It has been largely documented the beneficial effects of physical training on the endothelium-derived relaxing response by increasing nitric oxide production and/or its bioavailability to the smooth muscle [1]. L-carnitine (LCar) has been used as important supplement to regulate body composition associated with lipid metabolism. However, no studies exist investigating the effect of L-Car intake associated with dynamic exercise on the NO-independent sGC/cGMP pathway in the vascular responsiveness in rats. Thus, the aim of this work was to investigate the effect of L-Car supplementation on the NO-independent sGC/cGMP pathway in aortic and mesenteric rings in trained rats.

Effect of L-carnitine supplementation on the sGC/cGMP pathway in vascular relaxing responses from exercised rats