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Purpose Soluble guanylyl cyclase (sGC), which plays a pivotal role in penile erection, is a heterodimer build up by an α and a β subunit. For both subunits two isoforms have been characterized, but only the sGCα1β1 and sGCα2β1 isoforms seem to be functionally active. To elucidate the functional role of the sGCα1β1 heterodimer in the mechanism of erection, experiments were performed in vivo and on isolated corpora cavernosa (CC) using sGCα 1 −/− mice.

In vitro and in vivo studies on the importance of the soluble gyanylyl cyclase alpha 1 subunit in penile erection