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Conclusion The most important difference in the electrophysiological parameters (APD, Vmax) between HDC KO and WT mice could be due to the fact that HDC KO mice are more susceptible for hyperglycaemia. The results also suggest that rosiglitazone might act on K+ channels and this effect might take part in the protective effect of rosiglitazone in ischemia/reperfusion injury observed in rats, but further, direct ionic current measurements need to support this explanation.

bmc pharmacology

Electrophysiological characteristics of heart ventricular papillary muscles from histidine decarboxylase knockout and wild-type mice: effects of rosiglitazone