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Methods Pregnant Wistar rats were treated daily with MO (10 mg/ kg s.c.) from the day of mating until weaning (post partum day [PD] 21). Spontaneous MB (active nursing, passive nursing, littering and behaviours out of the nest) was checked on the 2nd, 3rd, 5th, 7th and 9th PDs. Analgesic affect of MO was measured in tail-flick test in the offspring on PD 23. Conditioned place preference (CPP) inducing effect of MO was checked in adult offspring.

Changes in the action of morphine challenge following perinatal morphine exposure in rats