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Human epidermal melanocytes represent a crucial protective barrier against UV irradiation and oxidative stress by generating the radical scavenging pigment melanin. Melanin is also known to act as a photosensitizer that generates active oxygen species upon UV irradiation, which may initiate hypopigmentary disorders (e.g., vitiligo) as well as UV-induced oncogene cell transformation. Finally, melanocytes in vivo are permanently targeted by environmental mechanical stimuli.

Melanocytes: interface of cell biology and pathobiology with a focus on nitric oxide and cGMP signaling