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Soluble guanylyl cyclase (sGC) is the recognized receptor for the nitric oxide (NO) messenger molecule. Binding of NO to the heme moiety of sGC activates the enzyme several hundred fold. In addition to NO several NO-independent allosteric regulators can activate the enzyme in heme-dependent (YC-1, BAY 41–2272) or heme-independent (BAY 58–2667) fashions. One of the early recognized NO-independent activators of sGC is protoporphyrin IX, a tetrapyrrole compound that actively substitutes for heme and binds to the heme-deficient sGC.

Fresh look on old substances – new class of NO-independent regulators of soluble guanylyl cyclase activity and function