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Nitric oxide (NO) is the most important relaxant neurotransmitter in the stomach. The principal target of NO is soluble guanylate cyclase (sGC), of which two physiologically prevailing isoforms exist, namely α1β1 and α2β1. The aim of this study was to investigate the role of sGC in NO-induced smooth muscle effects of gastric fundus and pylorus, and in gastric emptying, using wild type (WT) and sGCβ1his105phe mutant mice (7–14 weeks old).

NO-induced motility effects in gastric fundus and pylorus of sGCβ1his105phe mutant mice