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Stimulation of nitrergic neurons and endothelial cells in the erectile tissue results in release of NO that diffuse to surrounding smooth muscle cells where it activates the soluble guanylate cyclase (sGC), facilitating the conversion of GTP to cGMP. This second messenger diminishes the intracellular levels of calcium thereby causing penile smooth muscle relaxation and penile erection [1]. Epidemiological studies have shown a strong association between erectile dysfunction (ED) and arterial hypertension [2], where the deficiency of the NO-cGMP pathway seems to greatly contribute to such association [3]. Regular physical exercise has been shown to increase the NO production thus ameliorating cardiovascular diseases [2,4]. Recently, we have shown that prior physical conditioning improves the erectile function in normotensive rats [5] and prevents the impaired corpus cavernosum relaxation secondary to chronic NO blockade in rats [2].

Run training ameliorates the established erectile dysfunction in rats under long-term nitric oxide (NO) blockade