English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

genome contains 5 genes that code for sGC subunits. Twoof these, Gycα-99B and Gycβ-100B form a conventionalsGC and the remaining 3 genes code for atypical subunitsGyc-88E, Gyc-89Da and Gyc-89Db. When expressed inheterologous cells, Gyc-88E forms active homodimers,whereas Gyc-89Da and Gyc-89Db are only active whenco-expressed with Gyc-88E. We cannot detect any bio-chemical differences between Gyc-89Da and Gyc-89Db.The atypical sGCs are only stimulated 2–4 fold by NOdonors, whereas Gyc α-99B/Gycβ-100B is stimulated up to100 fold. The atypical sGCs, by contrast, are potently acti-vated when incubated in an oxygen-free environment.This activation is graded over 0-21% oxygen and can bedetected within 1 minute when cells expressing the subu-nits are exposed to 100% nitrogen. The sGC inhibitorODQ inhibits the activation. These biochemical proper-ties are consistent with a role as molecular oxygen sensorsand are also supported by studies in

Atypical soluble guanylyl cyclases in Drosophila as neutral oxygen sensors and their involvement in gestation