English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Resonance Raman (RR) spectra of soluble guanylate cyclase (sGC) reported by five independent research groups have been categorized into two types; sGC1 and sGC2. Here we demonstrate that the RR spectra of sGC isolated from bovine lung contains only sGC2 while both species are observed in the spectra of CO-bound form (CO-sGC). The relative populations of the two forms altered from an initial composition in which the CO-sGC2 form predominated, with the Fe-CO (νFe-CO) and C-O stretching modes (νCO) at 472 and 1985 cm-1, respectively, to a composition dominated by the CO-sGC1 form with νFe-CO and νCO at 488 and 1969 cm-1, following the addition of xenobiotic, YC-1. Further addition of a substrate, GTP, completed the change. GDP and cGMP had a similar but significantly smaller effect, while a substrate analogue, GTP-γ-S had an effect similar to that of GTP. In contrast, ATP had a reverse effect, and suppressed the effects of YC-1 and GTP. In the presence of both YC-1 and GTP, vinyl vibrations of heme were significantly influenced.

Resonance raman investigation of effects of YC-1 and GTP on structure of CO-bound heme of soluble guanylate cyclase