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Background There is still a need of further biomarkers for an early and correct diagnosis of PAH as mean time between onset of symptoms and diagnosis is two years. We investigated markers for pressure overload and markers for remodeling in two animal models of PAH, in order to differentiate between biomarker regulation due to afterload increase based on remodeling of pulmonary vessels (monocrotaline (MCT)-model) and isolated right ventricular pressure overload (pulmonary artery (PA) banding-model). The cGMP enhancing substance Sildenafil was utilized to investigate a response-to-treatment of the markers.

Biomarkers in two different animal models of pulmonary arterial hypertension (PAH) under treatment with a cGMP enhancing substance