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Cenderitide (CD-NP), a novel peptide designed to activate both guanylyl cyclase B and A, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure in a proof-of-concept study in patients with chronic heart failure Lisa C Costello-Boerrigter, John A Schirger, Wayne L Miller, Guido Boerrigter, Horng H Chen, Ruth Kempf, Candace Y Lee, John C Burnett Jr

bmc pharmacology

Cenderitide (CD-NP), a novel peptide designed to activate both guanylyl cyclase B and A, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure in a proof-of-concept study in patients with chronic heart failure