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Background Neuronal L-type voltage-gated calcium channels (LTCCs) have long been implicated in the regulation of excitability. This function appears to be related to the coupling of LTCC-mediated Ca influx to Ca-dependent conductances, such as KCa channels, e.g. KV2.x (SK), and nonspecific cation (CAN) channels. However, despite numerous data related to the molecular functioning of LTCCs, little is known about the actual role of these channels in cellular electrical excitation. In this study, we examined how activation of LTCCs affects neuronal depolarizations and analyzed the contribution of Ca-dependent potassium and cation conductances.

The interplay of excitatory and inhibitory coupling modes is crucial for the regulation of neuronal electrical activities by L-type calcium channels