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Background Lutein and zeaxanthin are carotenoids that are selectively taken up into the macula of the eye, where they may protect against development of age-related macular degeneration (AMD). Past studies have reported an agedependent decline of macular pigment optical density (MPOD) in patients with AMD. In the present study we investigated the age-dependence of MPOD and melatonin using spectral fundus reflectance. In addition, we hypothesized that patients with AMD have a reduced MPOD as compared to healthy controls.

The influence of lutein supplementation on macular pigment optical density in patients with dry AMD compared with healthy control subjects