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Background  Carbon tetra chloride (CCl 4 ), an industrial solvent, is a hepatotoxic agent and it is the well established animal model for free radical-induced liver injury. The present investigation was carried out to establish the protective effect of natansnin, a novel dibenzoyl glycoside from  Salvinia natans  against CCl 4  induced oxidative stress and cellular degeneration in rat liver.    Results  CCl 4  significantly increased the levels of lipid peroxides, oxidized glutathione and decreased the levels of reduced glutathione, SOD and CAT. CCl 4  induce marked histopathological changes and increase in the levels of apoptotic proteins. CCl 4  treatment significantly increased the levels of apoptotic proteins such as caspases-3, PARP, Bax, Bid and cytochrome C and also increased the levels of inflammatory mediators iNos and Cox-2. Natansnin treatment significantly decreased the levels of CCl 4  induced apoptotic proteins and inflammatory mediators. Further natansinin treatment significantly inhibited the CCl 4  induced apoptosis which was evident form the reduced TUNEL positive cells.    Conclusions  In conclusion, our study demonstrated the protective effect of natansnin against CCl 4  induced oxidative stress and cellular degeneration in rat liver tissue. This protective effect of natansnin can be correlated to its direct antioxidant effect.

bmc pharmacology

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver