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The problem of gain control in a neuron that faces thousands of synaptic stimuli has received much attention. Studies of relatively simple models established that synaptic gain can be modulated by multiple factors, such as presynaptic plasticity and/or intrinsic neuronal nonlinearities [1,2]. However, most central synapses are characterized by small active zones and high stochasticity of vesicular release [3]. In addition, dendritic trees abound with active conductances [4]. All of the above calls for a revised look at the simplified mean-field models of gain modulation.

Active dendritic conductances enhance processing of plastic synaptic stimuli