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The intrinsic mechanisms underlying burst generation in vitro where neurons are in relative isolation are generally well understood [1]. However, how these mechanisms are implemented under in vivo conditions where cells receive massive synaptic bombardment is still not clear. Pyramidal cells within the electrosensory lateral line lobe (ELL) of weakly electric fish have a well-defined burst mechanism in vitro (Fig. 1A), which is based on a somato-dendritic interaction [2]. Surprisingly, in vivo recordings from ELL pyramidal cells (Fig. 1B) do not show any of the characteristics associated with bursting found in vitro [3]. The goal of this project is to understand how in vivo conditions can give rise to these differences.

One cell, two bursting mechanisms. In vivo conditions change the in vitroburst in pyramidal cells of the ElectroLateral Lobe (ELL) of electric fish