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Neuronal dendrites contain thousands of synaptic inputs and are the first phase for signal processing. The activation of dendritic voltage dependent currents modulates the amplitude and time course of synaptic inputs, thus when the synaptic potential finally reaches the soma, it is a highly transformed version of the original input. In a previous publication [1] we simulated the effect of inhibition on the EPSP peak under various conditions of voltage dependent channel activation. In the present study we analyze the effects of similar conditions on EPSP time integral and its inhibition, since this parameter is also important in determining the firing pattern of a neuron.

A computer model of EPSP time integral modulation by the spatial distribution of dendritic voltage-dependent channels at a realistic α-motoneuron