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In our group we will develop an ultra-sensitive assay for early and non-invasive diagnosis of AD. This highly specific and sensitive assay uses fluorescence correlation spectroscopy (FCS) and is sensitive enough to detect even single aggregates. The principle of the assay has already been shown to be successful to detect prion-protein aggregates in brain homogenate (1). Prion-protein aggregates are the characteristic feature of prion diseases like bovine spongiform encephalopathy (BSE).

Development of an ultra-sensitive assay for early diagnosis of Alzheimer's disease