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Alpha-Synuclein (alpha-syn) is the major building block of cytoplasmic inclusions in neurodegenerative disorders named synucleinopathies, such as Parkinson's Disease and multiple system atrophy (MSA). In MSA glial cytoplasmic inclusions (GCIs) originating in oligodendrocytes are prominent. During disease progression a shift in alpha-syn solubility is observable, and oxidative modification of alpha-syn has been linked to neurodegeneration and fibril formation. Furthermore, an overlap of pathological features of patients with tauopathies, e.g. frontotemporal dementias including Pick's disease and progressive supranuclear palsy, has been reported, and it has been argued that alpha-syn aggregation can induce the fibrillization of tau.

Alpha-Synuclein aggregate formation in oligodendroglia OLN-t40 cells stably transfected with alpha-Synuclein