English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The effect of dopamine medication (L-Dopa and Dopamine (DA) agonists) and Deep Brain Stimulation (DBS) of Sub Thalamic Nucleus (STN) on the cognition of Parkinsonu0027s disease (PD) patients has been of interest to neuroscientists, owing to their ability to produce impulsive behavior as a side effect. Interestingly, it has been found that the impulsive decision making in STN-DBS patients has been observed to be quite contrary. As an attempt to understand the aforementioned side effect, we built a spiking network model of basal ganglia (BG) and tested on a probabilistic learning task [1]. BG nuclei such as Globus Pallidus externa (GPe), interna (GPi) and STN were represented as 2D arrays of Izhikevich neurons (50x50 lattice) and the activity of Striatal neurons (D1 and D2 receptor expressing Medium Spiny Neurons) as a Poisson process. Invoking the idea that DA cells in Substantia Nigra par compacta code for reward prediction error, similar to the temporal difference (TD) error term in Reinforcement learning, learning was introduced by updating the cortico-striatal weights using TD error. In the probabilistic learning task, the system was subjected to 3 pairs of stimuli (one at a time) randomly and the goal is to learn to select the most rewarding stimulus (=A) and avoid the punishing one (=B).The task had both training and testing stages where the model had to learn to make an optimal decision. The modelu0027s performance was tested on Healthy controls, PD in u0027OFFu0027, PD u0027ONu0027 (L-Dopa u0026 DA agonists) and finally on STN-DBS in terms of percentage accuracy and Reaction time (RT).

A spiking network model of basal ganglia to study the effect of dopamine medication and STN-DBS during probabilistic learning task