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Background  Microtubule-associated protein tau (MAPT) is a neuronal protein involved in the pathogenesis of several neurodegenerative diseases including Parkinson’s Disease (PD). Glycogen synthase kinase 3 beta (GSK3B) catalyzes phosphorylation in multiple sites of tau protein. However, whether or not there is any association between the  GSK3B  gene alteration,  MAPT  haplotype and PD remains unexplored in Chinese population, especially in central Chinese population.    Results  Here, we aimed at studying the effect of  MAPT  rs242562 and  GSK3B  rs334558 on the risk of PD by performing a case-control association study in central China. Our data showed that all PD patients and controls were of  MAPT  H1/H1 diplotype in our study, thus confirming that the distribution of the  MAPT  H1 haplotype is common in China. GG genotype of  MAPT  rs242562 serves protection effect on PD risk in central Chinese population, while genotype of  GSK3B  rs334558 showed no difference between PD patients and controls.    Conclusions  We conclude that the  MAPT  rs242562 is associated with PD in central China in the background of  MAPT  H1/H1 diplotype. The GG genotype of rs242562 displays protection against PD in subgroup with  GSK3B  rs334558 T carrier.

MAPT rs242562 and GSK3B rs334558 are associated with Parkinson’s Disease in central China