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Background  There are two widely used transient middle cerebral artery occlusion (MCAO) methods, which differ in the use of unilateral or bilateral carotid artery reperfusion (UNICAR and BICAR). Of the two methods, UNICAR is easier to perform. This study was designed to comprehensively compare the two reperfusion methods to determine if there are any differences in outcomes.    Results  The UNICAR and BICAR groups each included 9 rats .  At baseline, the average pO 2  was 20.54 ± 9.35 and 26.43 ± 7.39, for the UNICAR and BICAR groups, respectively ( P  = 0.519). Changes in pO 2 , as well as other physiological parameters measured within the ischemic lesion, were similar between the UNICAR and BICAR groups during 90 min of MCAO and the first 30 min of reperfusion (all  P  > 0.05). Furthermore, both the Bederson score and Garcia score, which are used for neurological assessment, were also similar (both  P  > 0.05). There were also no significant differences in T2WI lesion volume, DWI lesion volume, PWI lesion volume, or TTC staining infarct volume between the two groups (all  P  > 0.05).    Conclusion  UNICAR and BICAR have similar capability for inducing acute brain ischemic injury and can be considered interchangeable up to 24 hours after reperfusion.

Transient filament occlusion of the middle cerebral artery in rats: does the reperfusion method matter 24 hours after perfusion?