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In previous experiments [1], we showed that dendritic morphology affects the ability of passive neurons to recognise spatial patterns of synaptic inputs. In particular, the most symmetric morphologies outperformed the most asymmetric ones based on the measure of signalto-noise ratio between stored and novel patterns. In the present study, we analyse how the dendritic morphology affects the pattern recognition performance in active models. To evaluate pattern recognition performance, we ran a set of simulations using a large sample of neuronal morphologies each consisting of 128 terminal points and the same set of ion channel conductances, defined in previous models [2]. The model response was evaluated by calculating the signal-to-noise ratio over the number of spikes after presenting a pattern, differently from the experiments with passive models where the EPSP size was used [1,3]. For all experiments, we investigated whether the pattern recognition performance correlated with different morphometric parameters, including the asymmetry index [4], and the average and variance of path length. We also investigated suitable ranges for model parameters such as dendritic compartment length and synaptic strength, among other

The effect of dendritic morphology on pattern recognition in the presence of active conductances