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The cerebral cortex generates spontaneous activity organized in up and down states (<1 Hz) while in vitro [1]. This activity is similar to the cortical activity occurring during anesthesia and slow wave sleep [2]. Different studies have found that there is a delicate balance of excitation and inhibition during up states. Here we describe the effect of progressive blockade of inhibition on up states.

Inhibitory control of up states and their propagation in the cortical network