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Background  The halophilic archaeon  Halobacterium salinarum  expresses bacteriorhodopsin, a retinal-protein that allows photosynthetic growth. Transcription of the  bop  ( b acterio op sin) gene is controlled by two transcription factors, Bat and Brz that induce  bop  when cells are grown anaerobically and under light.    Results  A new gene was identified that is transcribed together with the  brz  gene that encodes a small basic protein designated as Brb ( b acteriorhodopsin- r egulating  b asic protein). The translation activity of the start codon of the  brb  gene was confirmed by BgaH reporter assays.  In vivo  site-directed mutagenesis of the  brb  gene showed that the Brb protein cooperates with Brz in the regulation of  bop  expression. Using a GFP reporter assay, it was demonstrated that Brb cooperates with both Brz and Bat proteins to activate  bop  transcription under phototrophic growth conditions.    Conclusions  The activation of the  bop  promoter was shown to be dependent not only on two major factors, Bat and Brz, but is also tuned by the small basic protein, Brb.

A small basic protein from the brz-brb operon is involved in regulation of bop transcription in Halobacterium salinarum