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Background  MCPIP is a novel CCCH zinc finger protein described as an RNase engaged in the regulation of immune responses. The regulation of expression of the gene coding for MCPIP -  ZC3H12A  is poorly explored.    Results  Here we report that the proinflammatory cytokine IL-1β rapidly induces the synthesis of MCPIP in primary monocyte-derived macrophages and HepG2 cells. This up-regulation takes place through the MAP kinase pathway and following activation of the transcription factor Elk-1. Using a  ZC3H12A  reporter construct we have shown that a  ZC3H12A  promoter region, stretching from -76 to +60, mediates activation by IL-1β. This region contains binding sites for Elk-1 and its partner SRF. Chromatin immunoprecipitation analysis confirms  in vivo  binding of both transcription factors to this region of the  ZC3H12A  promoter.    Conclusions  We conclude that the transcription factor Elk-1 plays an important role in the activation of  ZC3H12A  expression in response to IL-1β stimulation.

Transcription factors Elk-1 and SRF are engaged in IL1-dependent regulation of ZC3H12A expression