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Background  The aim of the study was to detect whether in experimental  Salmonella enterica  Typhimurium infection the probiotic  Lactobacillus fermentum  ME-3 in combination with fluoroquinolone therapy would eradicate  S.  Typhimurium, prevent the development of liver and spleen granulomas and improve the indices of oxidative stress in the ileum mucosa.  The selected bacteriological, histological and biochemical methods were applied.    Results  Combined treatment with  L. fermentum  ME-3 and ofloxacin eradicated  Salmonella  Typhimurium from blood, ileum and liver, decreased the number of animals with liver and spleen granulomas and reduced the value of lipid peroxides in the ileum mucosa. Higher total counts of intestinal lactobacilli in all experimental groups were associated with the absence of liver granulomas.    Conclusion  The antimicrobial and antioxidative probiotic  L. fermentum  ME-3 combined with ofloxacin enhances the eradication of experimental  S . Typhimurium infection. These observations on probiotic and antimicrobial co-action may serve as basis to develop new strategies for treatment of invasive bacterial infections of the gut.

bmc microbiology

Eradication of Salmonella Typhimurium infection in a murine model of typhoid fever with the combination of probiotic Lactobacillus fermentum ME-3 and ofloxacin