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Background  In recent years it has become clear that small non-coding RNAs function as regulatory elements in bacterial virulence and bacterial stress responses. We tested for the presence of the small non-coding GcvB RNAs in  Y. pestis  as possible regulators of gene expression in this organism.    Results  In this study, we report that the  Yersinia pestis  KIM6  gcvB  gene encodes two small RNAs. Transcription of  gcvB  is activated by the GcvA protein and repressed by the GcvR protein. The  gcvB -encoded RNAs are required for repression of the  Y. pestis dppA  gene, encoding the periplasmic-binding protein component of the dipeptide transport system, showing that the GcvB RNAs have regulatory activity. A deletion of the  gcvB  gene from the  Y. pestis  KIM6 chromosome results in a decrease in the generation time of the organism as well as a change in colony morphology.    Conclusion  The results of this study indicate that the  Y. pestis gcvB  gene encodes two small non-coding regulatory RNAs that repress  dppA  expression. A  gcvB  deletion is pleiotropic, suggesting that the sRNAs are likely involved in controlling genes in addition to  dppA .

The Yersinia pestis gcvB gene encodes two small regulatory RNA molecules