English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Biosurfactants (BS) are amphiphilic compounds produced by microbes, either on the cell surface or secreted extracellularly. BS exhibit strong antimicrobial and anti-adhesive properties, making them good candidates for applications used to combat infections. In this study, our goal was to assess the  in vitro  antimicrobial, anti-adhesive and anti-biofilm abilities of BS produced by  Lactobacillus jensenii  and  Lactobacillus rhamnosus  against clinical Multidrug Resistant (MDR) strains of  Acinetobacter baumannii ,  Escherichia coli , and  Staphylococcus aureus  (MRSA). Cell-bound BS from both  L. jensenii  and  L. rhamnosus  were extracted and isolated. The surface activities of crude BS samples were evaluated using an oil spreading assay. The antimicrobial, anti-adhesive and anti-biofilm activities of both BS against the above mentioned MDR pathogens were determined.    Results  Surface activities for both BS ranged from 6.25 to 25 mg/ml with clear zones observed between 7 and 11 cm. BS of both  L. jensenii  and  L. rhamnosus  showed antimicrobial activities against  A. baumannii ,  E. coli  and  S. aureus  at 25-50 mg/ml. Anti-adhesive and anti-biofilm activities were also observed for the aforementioned pathogens between 25 and 50 mg/ml. Finally, analysis by electron microscope indicated that the BS caused membrane damage for  A. baumannii  and pronounced cell wall damage in  S. aureus .    Conclusion  Our results indicate that BS isolated from two Lactobacilli strains has antibacterial properties against MDR strains of  A. baumannii, E. coli  and MRSA. Both BS also displayed anti-adhesive and anti-biofilm abilities against  A. baumannii ,  E. coli  and  S. aureus . Together, these capabilities may open up possibilities for BS as an alternative therapeutic approach for the prevention and/or treatment of hospital-acquired infections.

Antimicrobial and antibiofilm potential of biosurfactants isolated from lactobacilli against multi-drug-resistant pathogens