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Background  Coagulase-negative staphylococci (CoNS) are opportunistic pathogens found as colonisers of the human gut. This study was carried out to examine the genetic resistance mechanisms in faecal isolates of CoNS. The study investigated 53 non-duplicate CoNS isolates obtained from the fresh stool samples of apparently healthy subjects in the community of Ile-Ife, South-Western Nigeria. Antibiotic susceptibility testing was assessed by the disc diffusion test while antibiotic resistance genes were analysed by PCR.  mecA  positive isolates were analysed by Staphylococcal Chromosome Cassette  mec  (SCC mec ) and cassette chromosome recombinase ( ccr ) complex typing methods.    Results  Resistance genes were detected only in isolates that showed resistance by phenotypic screening. The  aac(6′)–aph(2″)  gene was detected in all the three isolates resistant to gentamicin. Four of the five erythromycin resistant isolates were positive for the  ermC  gene ,  the remaining isolate carried the  msrA  gene. The  tetK  gene was detected in 6 of the 7 tetracycline resistant isolates while 4 possessed the  tetM  gene. Three of the isolates ( S. haemolyticus ,  S. xylosus  and  S. capitis ) had both genes. Several SCC mec  types were found: SCC mec  I-  ccrAB β2-α2 (4 isolates: 3  S. epidermidis , 1  S. warneri ), SCC mec IVb-  ccrAB β2-α3 (1 isolate:  S. epidermidis ), SCC mec IVd-  ccrAB β2-α3 (8 isolates: 3  S. epidermidis , 2  S. xylosus , 1  S. saprophyticus , 1  S. warneri , 1  S. capitis ), and untypable (2 isolates:  S. epidermidis ).    Conclusion  This genetic background could be a reservoir for interspecies gene transfer among CoNS and  S. aureus  in the intestinal tract.

bmc microbiology

Diversity of antibiotic resistance genes and staphylococcal cassette chromosome mec elements in faecal isolates of coagulase-negative staphylococci from Nigeria