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Background   Staphylococcus aureus  is an opportunistic commensal bacterium that mostly colonizes the skin and soft tissues. The pathogenicity of  S. aureus  is due to both its ability to resist antibiotics, and the production of toxins. Here, we characterize a group of genes responsible for toxin production and antibiotic resistance of  S. aureus  strains isolated from skin, soft tissue, and bone related infections.    Results  A total of 136  S. aureus  strains were collected from five different types of infection: furuncles, pyomyositis, abscesses, Buruli ulcers, and osteomyelitis, from hospital admissions and out-patients in Benin. All strains were resistant to benzyl penicillin, while 25% were resistant to methicillin, and all showed sensitivity to vancomycin. Panton-Valentine leukocidin (PVL) was the most commonly produced virulence factor (70%), followed by staphylococcal enterotoxin B (44%). Exfoliative toxin B was produced by 1.3% of the strains, and was only found in isolates from Buruli ulcers. The  tsst-1 ,  sec , and  seh  genes were rarely detected (≤1%).    Conclusions  This study provides new insight into the prevalence of toxin and antibiotic resistance genes in  S. aureus  strains responsible for skin, soft tissue, and bone infections. Our results showed that PVL was strongly associated with pyomyositis and osteomyelitis, and that there is a high prevalence of PVL-MRSA skin infections in Benin.

bmc microbiology

Variability of antibiotic susceptibility and toxin production of Staphylococcus aureus strains isolated from skin, soft tissue, and bone related infections