English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Corynebacterium ulcerans  can cause a diphtheria-like illness, especially when the bacterium is lysogenized with a  tox  gene-carrying bacteriophage that produces diphtheria toxin. Acquisition of toxigenicity upon phage lysogenization is a common feature of  C. ulcerans  and  C. diphtheriae . However, because of a lack of  C. ulcerans  genome information, a detailed comparison of prophages has not been possible between these two clinically important and closely related bacterial species.    Results  We determined the whole genome sequence of the toxigenic  C. ulcerans  0102 isolated in Japan. The genomic sequence showed a striking similarity with that of  Corynebacterium pseudotuberculosis  and, to a lesser extent, with that of  C. diphtheriae . The 0102 genome contained three distinct prophages. One of these, ΦCULC0102-I, was a  tox -positive prophage containing genes in the same structural order as for  tox -positive  C. diphtheriae  prophages. However, the primary structures of the individual genes involved in the phage machinery showed little homology between the two counterparts.    Conclusion  Taken together, these results suggest that the  tox -positive prophage in this strain of  C. ulcerans  has a distinct origin from that of  C. diphtheriae  NCTC 13129.

Corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the C. diphtheriae NCTC 13129 prophage