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Background  The cAMP receptor protein (CRP) is a global bacterial regulator that controls many target genes. The CRP-cAMP complex regulates the  ompR-envZ  operon in  E. coli  directly, involving both positive and negative regulations of multiple target promoters; further, it controls the production of porins indirectly through its direct action on  ompR-envZ . Auto-regulation of CRP has also been established in  E. coli . However, the regulation of porin genes and its own gene by CRP remains unclear in  Y. pestis .    Results   Y. pestis  employs a distinct mechanism indicating that CRP has no regulatory effect on the  ompR-envZ  operon; however, it stimulates  ompC  and  ompF  directly, while repressing  ompX . No transcriptional regulatory association between CRP and its own gene can be detected in  Y. pestis , which is also in contrast to the fact that CRP acts as both repressor and activator for its own gene in  E. coli . It is likely that  Y. pestis  OmpR and CRP respectively sense different signals (medium osmolarity, and cellular cAMP levels) to regulate porin genes independently.    Conclusion  Although the CRP of  Y. pestis  shows a very high homology to that of  E. coli , and the consensus DNA sequence recognized by CRP is shared by the two bacteria, the  Y. pestis  CRP can recognize the promoters of  ompC ,  F , and  X  directly rather than that of its own gene, which is different from the relevant regulatory circuit of  E. coli . Data presented here indicate a remarkable remodeling of the CRP-mediated regulation of porin genes and of its own one between these two bacteria.

Regulatory effects of cAMP receptor protein (CRP) on porin genes and its own gene in Yersinia pestis