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Background  Human memory CD4 +  T cells can be either CD300a/c +  or CD300a/c -  and subsequent analyses showed that CD4 +  effector memory T (T EM ) cells are mostly CD300a/c + , whereas CD4 +  central memory T (T CM ) cells have similar frequencies of CD300a/c +  and CD300a/c -  cells.    Results  Extensive phenotypical and functional characterization showed that in both T CM  and T EM  cells, the CD300a/c +  subset contained a higher number of T H 1 (IFN-γ producing) cells. Alternatively, T H 17 (IL-17a producing) cells tend to be CD300a/c - , especially in the T EM  subset. Further characterization of the IL-17a +  cells showed that cells that produce only this cytokine are mostly CD300a/c - , while cells that produce IL-17a in combination with other cytokines, especially IFN-γ, are mostly CD300a/c + , indicating that the expression of this receptor is associated with cells that produce IFN-γ. Co-ligation of the TCR and CD300a/c in CD4 +  T cells inhibited Ca 2+  mobilization evoked by TCR ligation alone and modulated IFN-γ production on T H 1 polarized cells.    Conclusion  We conclude that the CD300a/c receptors are differentially expressed on human T H 1 and T H 17 cells and that their ligation is capable of modulating TCR mediated signals.

Differential expression of CD300a/c on human TH1 and TH17 cells